What this tool estimates
- A single probability that a stimulation cycle produces at least one euploid embryo, using age and AMH as inputs.
- This is not a prediction of pregnancy, implantation, or live birth.
Inputs
- Age (years): accepted range 29 to 44. Outside this range, the estimate is not shown.
- AMH (ng/mL): must be a number 0 or higher. Non-numeric entries are blocked.
How the estimate is built
- Age drives euploid rates: Embryo aneuploidy rises with maternal age in large PGT-A datasets. This tool uses an internal age curve shaped to published age patterns (see Sources).
- AMH is used as a quantity signal: AMH is primarily used to estimate expected ovarian response (oocyte quantity), not embryo genetics. This tool uses AMH to scale the expected number of embryos available for testing/transfer (see Sources).
- At least one euploid embryo: The tool combines the age-based euploid proportion with the AMH-scaled embryo count using a standard “at least one success” calculation:
P(at least 1) = 1 - (1 - p_euploid) ^ n
wherep_euploidcomes from the age curve andnis the AMH-scaled embryo count. - Guardrails: The final probability is clamped to 0 to 100% to avoid impossible outputs.
Output & display rules
- Primary output: “Chance of at least 1 euploid embryo” rounded to 1 decimal place (with a <0.1% floor label for very small values).
- Status text: echoes the age and AMH used to compute the estimate.
Assumptions & limitations
- AMH helps estimate likely response (how many eggs), but it does not measure egg or embryo genetic health. Age remains the strongest driver of aneuploidy patterns.
- Real outcomes vary with stimulation protocol, lab conditions, fertilisation method, embryo culture, and patient factors not captured here.
- PGT-A has technical limits, including mosaic results and false calls. This tool does not model those testing limits.
Sources
- Franasiak JM, Forman EJ, Hong KH, et al. The nature of aneuploidy with increasing age of the female partner. Fertil Steril. 2014;101(3):656-663.e1. doi:10.1016/j.fertnstert.2013.11.004.
- Cedars MI. Evaluation of Female Fertility – AMH and Ovarian Reserve Testing. J Clin Endocrinol Metab. 2022;107(6):1510-1519. doi:10.1210/clinem/dgac039.
- Endotext (NCBI Bookshelf). Ovarian Reserve Testing. Updated review chapter discussing AMH/AFC for predicting ovarian response.
- Practice Committees of ASRM and SART. The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion. Fertil Steril. 2018;109(3):429-436. doi:10.1016/j.fertnstert.2018.01.002.
- Shetty S, et al. Preimplantation genetic testing for aneuploidy (PGT-A) – a single-center experience. J Assist Reprod Genet. 2022. (Open access; includes age-related aneuploidy patterns.)
How to use this euploid embryo calculator
- Enter your AMH level in ng/mL (e.g., 2.4).
- Enter your age in years.
- Click Calculate to see:
- Chance of at least one euploid embryo from a stimulation cycle
- a short note on how your AMH compares with an age-specific anchor (“T50”)
Guardrails: the current model supports ages ~29–44 years. Very low/high AMH values may trigger warnings.
Understanding your results
Chance of ≥1 euploid embryo
This answers: “If we retrieve and culture expected embryos, what’s the probability that at least one is chromosomally normal (euploid)?”
Per-embryo euploid rate
An age-based estimate of the proportion of embryos expected to be euploid. As maternal age rises, this percentage typically declines.
Expected blastocyst count
AMH helps approximate the number of embryos that may reach blastocyst stage after stimulation and culture. The tool combines this with your age to project a reasonable range.
Important context
- Quality vs quantity: AMH tracks egg quantity, not chromosome quality.
- Clinic & protocol factors: Stimulation approach, lab variability, and day-3 vs day-5 culture can shift actual outcomes.
- PGT-A: Genetic testing reports embryo ploidy directly; this calculator provides a planning-stage estimate only.
Euploid probability: FAQs
Does AMH measure embryo quality?
No. AMH reflects egg supply, not chromosomal quality. Age is the dominant driver of euploidy. For AMH ranges and interpretation, see the AMH levels by age tool.
How accurate is this calculator?
It’s a planning-stage estimate using age-based euploid curves and an AMH-informed blastocyst expectation. Real outcomes vary by stimulation protocol, lab performance, and individual biology. PGT-A is the only way to determine embryo ploidy directly.
How many eggs do I need for one euploid embryo?
It depends on age (euploid rate) and how many embryos reach blastocyst. The model shows both pieces: a per-embryo euploid percentage and expected blast count. If you’re family-building over time, you may also consider the egg freezing success rate tool for strategy.
Does day-3 vs day-5 culture change results?
Culture strategy affects how many embryos reach testing/transfer. The euploid rate is largely age-related, but the number of testable/transferable embryos can differ. For transfer considerations, see embryo grade success rate.
Can male factor change euploid probability?
Severe sperm DNA fragmentation or very low counts may impact embryo development. Use the semen analysis & TMSC interpreter for context and discuss with your clinic.
How does this relate to IVF success rates?
Euploid embryos generally have higher implantation potential. For age-stratified clinical outcomes, compare with the IVF success rate by age calculator.
This calculator uses age-based euploid probability curves and an AMH-informed estimate of blastocyst yield to produce a planning-stage estimate. It’s intended for education and shared decision-making—please discuss your individual plan and protocol with your clinician.